從 2018 年引進單細胞實驗平臺，到 2019 年烈冰助力第一篇單細胞文章，

在單細胞領域烈冰助力用戶發表單細胞文獻 100+ 篇 (不完全統計)，總 IF>1400+!

包含Nature、Cancer cell、Immunity、Circulation、Journal of Infection、Cell Discovery、Nature Neuroscience、GUT、Science Immunology、Nature Cell Biology、Nature Plants等生物領域國際頂尖學術期刊，

已發表文章研究領域涵蓋免疫、腫瘤、腦科學、牙科、骨科、疫苗研究、植物等各個領域。

2023 年，截止到今天，助力用戶發表單細胞文獻 36篇，平均IF超15!

2023
取得佳績

免疫研究領域

1、A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency

期刊：Science Immunology

研究方向：免疫缺陷

2、Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

期刊：Nature Communications

研究方向：腫瘤免疫逃逸

解讀鏈接：https://mp.weixin.qq.com/s/kgrIrpWkCmV5V02ZKigq3A

3、Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas

期刊：Journal of Infection

研究方向：結核病免疫失調

解讀鏈接：https://mp.weixin.qq.com/s/3igJ9rBCmFfazqVxPbCpCw

4、Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment

期刊：Nature Communications

研究方向：胰腺癌免疫微環境

解讀鏈接：https://mp.weixin.qq.com/s/99RdAfqjmig7W55UPROmmA

5、Targeting neoadjuvant chemotherapy-induced metabolic reprogramming in pancreatic cancer promotes anti-tumor immunity and chemo-response

期刊：Cell Reports Medicine

研究方向：免疫治療

6、Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

期刊：Science Advances

研究方向：免疫治療

解讀鏈接：https://mp.weixin.qq.com/s/o4CMJ5Wlelb3i4YKmJo_hA

以上為烈冰生物2023最新助力在免疫研究領域的高分單細胞測序文獻，更多助力文獻可關注公眾號或聯系駐地銷售獲取更詳細文獻列表~

腫瘤研究領域

1、Single-Cell Landscape Highlights Heterogenous Microenvironment, Novel Immune Reaction Patterns,Potential Biomarkers and Unique Therapeutic Strategies of Cervical Squamous Carcinoma, Human Papillomavirus-Associated(HPVA) and Non-HPVA Adenocarcinoma

期刊：Advanced Science

研究方向：宮頸鱗癌

2、NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma

期刊：GUT

研究方向：胃賁門腺癌

3、Single-cell and spatial dissection of precancerous lesions underlying the initiation

process of oral squamous cell carcinoma

期刊：Cell Discovery

研究方向：口腔鱗癌

4、Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

期刊：Cancer Cell

研究方向：前列腺癌

解讀鏈接：https://mp.weixin.qq.com/s/JVBKNLuOCRX35yVEl2KHyA

5、TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis

期刊：Advanced Science

研究方向：肝癌

6、Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1therapy in HCC by mediating irreversible exhaustion of T cells

期刊：Journal of Hepatology

研究方向：肝癌

解讀鏈接：https://mp.weixin.qq.com/s/bRJnFxZgJ7saRGQqQNn-UA

7、ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein

期刊：Advanced Science

研究方向：腸道腫瘤

以上為烈冰生物2023最新助力在腫瘤研究領域的高分單細胞測序文獻，更多助力文獻可關注公眾號或聯系駐地銷售獲取更詳細文獻列表~

神經研究領域

1、Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors

期刊：Nature Neuroscience

研究方向：抑郁癥

解讀鏈接：https://mp.weixin.qq.com/s/BdUfrluolINoQ2ayD5BFZQ

2、Single-nucleus profiling of adult mice sub-ventricular zone after blast-related traumatic brain injury

期刊：Scientific Data

研究方向：腦損傷

3、Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke

期刊：Journal of Neuroinflammation

研究方向：腦缺血性卒中

4、Single-nucleus transcriptomic mapping of blast-induced traumatic brain injury in mice hippocampus

期刊：Scientific Data

研究方向：腦損傷

以上為烈冰生物2023最新助力在神經研究領域的高分單細胞測序文獻，更多助力文獻可關注公眾號或聯系駐地銷售獲取更詳細文獻列表~